Scientist II - LC/MS

Scientist II - LC/MS and HPLC
Lake County, IL
6+ month initial contract (renewable)
Hourly Pay Rate: $43-46/hr (medical benefits available at a cost)

Our global pharmaceutical client is hiring! Their Quantitative, Translational ADME Sciences (QTAS) department is seeking a highly motivated scientist to join the Biologics Bioanalysis, Characterization, and Proteomics (BBCP) group in North Chicago, IL.

This position primarily involves conducting LC/MS-based bioanalysis assays on biologic entities including monoclonal antibodies, antibody drug conjugates (ADC), fusion proteins, etc., to provide essential support for in vitro stability, pre-clinical PK, PK/PD, and Toxicology studies. The candidate will be responsible for sample preparation, bioanalytical assay operations, method development, instrument operation and maintenance, data analysis and report generation. This is a 6-month contractor position.

Key tasks and responsibilities:
* Implement bioanalytical methods for quantifying antibodies, ADCs, fusion proteins, peptides, and small molecules using triple quad LC-MS/MS.
* Characterization of antibodies, ADCs, fusion proteins, peptides using intact MS and peptide mapping with high-res MS platforms.
* Routinely assist with sample incubation and preparation for serum stability studies.
* Routinely operate LC-MS and automation instrumentation, including maintenance and troubleshooting.
* Analyze and present data to project teams and stakeholders.
* Utilize and maintain electronic laboratory notebooks for study documentation.
* Support study data entry and archival to RLIMS.

Education and Experience:
* M.S. (2+ years), or B.S. (5+ years) of experience in pharmaceutical or biotechnology industry.
* Highly motivated individual with a strong intellectual and technical background in LC-MS analysis is required. Experience in large-molecule LC-MS bioanalysis is an advantage.
* Direct hands-on experience and/or strong trouble shooting skills in LC-MS bioanalytical laboratory is required. Experience with Triple quad MS (SCIEX), QTOF MS (Agilent) is preferred.
* Utilization of electronic sample management tools and automation systems is a plus.
* High level of attention to detail and proficiency in analytical, organizational, and interpersonal skills.
* Excellent verbal and written communications skills and ability to work independently and excel in a team environment.

What are the top 3-5 skills, experience or education required for this position:
* Competency with QTOF (Agilent) and Triple Quad (Sciex) LCMS systems.
* Competency with Analyst, Protein Metrics, BioConfirm for data analysis.
* Experience with sample preparation with biological matrices to enable quantification and characterization studies.
* Familiarity working with large molecules - protein characterization, intact mass, and peptide mapping analysis is highly desired
* A strong understanding of quantitative analysis, including utilization of calibration curves, internal standards, QCs, basic statistics
* Must be able to maintain HPLC and LCMS for routine operations

Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.